Abstract

This proposal expands the research scope of the parent grant (R01 AG033906) by investigating biological markers reflecting predisposing factors for and the stress-related consequences of chronic pain. Consistent with the OppNet priorities, this proposal targets an improved understanding of the complex interaction of biopsychosocial factors on health outcomes. Two biological measures associated with psychosocial stress, accelerated aging, and morbidity;telomere length (TL) and telomerase activity (TA), will be incorporated into the study design which includes assessment of pain severity, functional limitations, and measures of pain-related psychological risk factors and psychosocial stress (e.g., perceived stress and experiences of discrimination). The overall aim of this competitive revision is determine the influence of chronic pain and psychosocial stress on TL and TA among older African American (AA) and non- Hispanic white (NHW) individuals with knee osteoarthritis (OA) as well as age and ethnicity-matched healthy controls. The relationships between telomere measures, experiences of chronic pain, behavioral and social factors, and potential ethnic differences, have not yet been investigated. The goal of this competitive revision is to better understand the interaction between biological processes and behavioral and social variables in ethnically diverse older adults with and without chronic OA-related pain, to determine the utility of TL and TA as tools in assessing system burden resulting from chronic pain and/or other biopsychosocial variables, and to identify vulnerability and resilience factors.

Public Health Relevance

Evidence suggests that chronic psychosocial stress may be a significant contributor to pain- related ethnic group differences. We intend to evaluate biological markers of psychosocial stress and chronic pain in a large multi-ethnic sample of patients with and without knee osteoarthritis. This information will proved an improved understanding of inter-individual variability in chronic pain, help identify behavioral and social targets for prevention and treatment, and provide a mechanism for evaluating the efficacy of clinical interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG033906-07S1
Application #
8038785
Study Section
Special Emphasis Panel (ZRG1-RPHB-E (85))
Program Officer
Nielsen, Lisbeth
Project Start
2009-04-01
Project End
2012-08-31
Budget Start
2010-09-30
Budget End
2012-08-31
Support Year
7
Fiscal Year
2010
Total Cost
$219,658
Indirect Cost

  Institution

Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Sibille, Kimberly T; King, Christopher; Garrett, Timothy J et al. (2018) Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain. Clin J Pain 34:182-189
Thompson, Kathryn A; Bulls, Hailey W; Sibille, Kimberly T et al. (2018) Optimism and Psychological Resilience are Beneficially Associated With Measures of Clinical and Experimental Pain in Adults With or at Risk for Knee Osteoarthritis. Clin J Pain 34:1164-1172
Herbert, Matthew S; Goodin, Burel R; Bulls, Hailey W et al. (2017) Ethnicity, Cortisol, and Experimental Pain Responses Among Persons With Symptomatic Knee Osteoarthritis. Clin J Pain 33:820-826
Sibille, Kimberly T; Steingrímsdóttir, Ólöf A; Fillingim, Roger B et al. (2016) Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Res Manag 2016:7657329
Cardoso, Josue S; Riley 3rd, Joseph L; Glover, Toni et al. (2016) Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis. Pain 157:2104-14
Bartley, Emily J; King, Christopher D; Sibille, Kimberly T et al. (2016) Enhanced Pain Sensitivity Among Individuals With Symptomatic Knee Osteoarthritis: Potential Sex Differences in Central Sensitization. Arthritis Care Res (Hoboken) 68:472-80
Bulls, Hailey W; Goodin, Burel R; McNew, Myriah et al. (2016) Minority Aging and Endogenous Pain Facilitatory Processes. Pain Med 17:1037-48
Petrov, Megan E; Goodin, Burel R; Cruz-Almeida, Yenisel et al. (2015) Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis. J Pain 16:478-90
Glover, Toni L; Goodin, Burel R; King, Christopher D et al. (2015) A Cross-sectional Examination of Vitamin D, Obesity, and Measures of Pain and Function in Middle-aged and Older Adults With Knee Osteoarthritis. Clin J Pain 31:1060-7
Herbert, Matthew S; Goodin, Burel R; Pero 4th, Samuel T et al. (2014) Pain hypervigilance is associated with greater clinical pain severity and enhanced experimental pain sensitivity among adults with symptomatic knee osteoarthritis. Ann Behav Med 48:50-60

Showing the most recent 10 out of 34 publications