Abstract

Studies on the maturation of the B-cell population are proposed. The role of the thymus in regulating the maturation of the function of the B-cell population will be studied. Three aspects of B-cell function will be evaluated: (1) ontogeny of the capacity to produce a heterogeneous response to a T-independent antigen; (2) ontogeny of the capacity to resynthesize surface immunoglobulin after capping with anti-immunoglobulin; (3) the ontogeny of the resistance to tolerance induction which is typical of mature B cells. The studies will be carried out using cell transfer methods to evaluate the function of B cells from donors of various ages transferred into lethally irradiated adult recipients. The influence of thymus cells on B-cell maturation will be evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI011694-11
Application #
3125001
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1977-06-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Van Vollenhoven, R F; Thorbecke, G J; Siskind, G W (1990) Exposure of female mice to type II collagen reduces susceptibility to collagen-induced arthritis in offspring. Eur J Immunol 20:2149-52
Gulati, P; Falck-Pedersen, E; Siskind, G W (1989) Regulation of antibody secretion by hybridoma cells. II. Mechanism of idiotype-induced suppression of antibody secretion by hybridoma cells. Cell Immunol 123:276-82
Siskind, G W; Arreaza, E (1989) Network regulation of the immune response. Allergy Proc 10:387-91
Kim, Y T; Deblasio, T; Thorbecke, G J et al. (1989) Production of auto-anti-idiotype antibody during the normal immune response. XIV. Evidence for the antigen-independent operation of the idiotype network. Immunology 67:191-6
Brown, D W; Kim, Y T; Siskind, G W (1989) The influence of immune complexes, steric effects, and antigen-antigen interactions on the sensitivity of enzyme-linked immunosorbent assays. J Immunol Methods 116:45-51
Marcenaro, L; Russo, C; Kim, Y T et al. (1989) Immunological studies of aging. Normal B-cell repertoire in aged mice: studies at a clonal level. Cell Immunol 119:202-10
van Vollenhoven, R F; Nagler-Anderson, C; Soriano, A et al. (1988) Tolerance induction by a poorly arthritogenic collagen II can prevent collagen-induced arthritis. Cell Immunol 115:146-55
Tsuda, T; Kim, Y T; Siskind, G W et al. (1988) Old mice recover the ability to produce IgG and high-avidity antibody following irradiation with partial bone marrow shielding. Proc Natl Acad Sci U S A 85:1169-73
Coico, R F; Finkelman, F; Swenson, C D et al. (1988) Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro. Proc Natl Acad Sci U S A 85:559-63
Swenson, C D; Van Vollenhoven, R F; Xue, B et al. (1988) Physiology of IgD. IX. Effect of IgD on immunoglobulin production in young and old mice. Eur J Immunol 18:13-20

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