The overall aim of this proposal is to develop and to evaluate methods for reducing the risk for hospitalized patients of acquiring urinary tract infections associated with the temporary use of indwelling bladder catheters. We believe that effective control measures must be based on a sound understanding of the epidemiology and pathogenesis of catheter-associated infections. Toward this objective, we have established a program for the daily bacteriologic monitoring of urinary drainage systems, and, using a unique computerized medical records system developed techniques for implementing prospective randomized, controlled studies of preventive methods. We have identified bacterial colonization of the urethral meatuscatheter junction as an important risk factor for later bacteriuria. In the proposed studies, we will use our monitoring system to evaluate the epidemiologic determinants and dynamics of meatal colonization with potentially pathogenic bacteria, determine the relative importance of endogenous versus exogenous sources for bacteriuria, and devise new strategies for blocking ascending infectrion in the space between the catheter and the urethral epithelium. We also propose to define the epidemiology of catheter-asso-ciated infections due to gram-positive cocci and yeast, which are of growing importance and have received less attention in previous work. Specific intervention studies that are planned include evaluations of hydrophilicpolymer coated silicone catheters in conjunction with intra-urethral disinfection with povidone-iodine gel and daily meatal care using a polyantibiotic cream; of periodic instillation of hydrogen peroxide into drainage bags; and of continuous bladder irrigation with povidone-iodine solution.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015655-06
Application #
3126327
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1979-05-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Lds Hospital
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84143
Riley, D K; Classen, D C; Stevens, L E et al. (1995) A large randomized clinical trial of a silver-impregnated urinary catheter: lack of efficacy and staphylococcal superinfection. Am J Med 98:349-56
Huth, T S; Burke, J P; Larsen, R A et al. (1992) Randomized trial of meatal care with silver sulfadiazine cream for the prevention of catheter-associated bacteriuria. J Infect Dis 165:14-8
Huth, T S; Burke, J P; Larsen, R A et al. (1992) Clinical trial of junction seals for the prevention of urinary catheter-associated bacteriuria. Arch Intern Med 152:807-12
Classen, D C; Larsen, R A; Burke, J P et al. (1991) Daily meatal care for prevention of catheter-associated bacteriuria: results using frequent applications of polyantibiotic cream. Infect Control Hosp Epidemiol 12:157-62
Classen, D C; Larsen, R A; Burke, J P et al. (1991) Prevention of catheter-associated bacteriuria: clinical trial of methods to block three known pathways of infection. Am J Infect Control 19:136-42
Burke, J P; Classen, D C; Pestotnik, S L et al. (1991) The HELP system and its application to infection control. J Hosp Infect 18 Suppl A:424-31
Evans, R S; Pestotnik, S L; Burke, J P et al. (1990) Reducing the duration of prophylactic antibiotic use through computer monitoring of surgical patients. DICP 24:351-4
Larsen, R A; Evans, R S; Burke, J P et al. (1989) Improved perioperative antibiotic use and reduced surgical wound infections through use of computer decision analysis. Infect Control Hosp Epidemiol 10:316-20
Larsen, R A; Curtis, E T; Jacobson, J A et al. (1987) Trends in infections and antibiotic usage in a community hospital. Am J Infect Control 15:7-15
Burke, J P; Larsen, R A; Stevens, L E (1986) Nosocomial bacteriuria: estimating the potential for prevention by closed sterile urinary drainage. Infect Control 7:96-9

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