Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI018619-07
Application #
3128057
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1982-04-01
Project End
1992-10-31
Budget Start
1990-04-01
Budget End
1992-10-31
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Froberg, M K; Fitzgerald, T J; Hamilton, T R et al. (1993) Pathology of congenital syphilis in rabbits. Infect Immun 61:4743-9
Tomai, M A; Fitzgerald, T J; Froberg, M K (1992) Macrophage and lymphocyte functions are down-regulated in newborn rabbits. J Leukoc Biol 51:151-6
Fitzgerald, T J; Froberg, M K (1991) Congenital syphilis in newborn rabbits: immune functions and susceptibility to challenge infection at 2 and 5 weeks of age. Infect Immun 59:1869-71
Fitzgerald, T J; Tomai, M A (1991) Splenic T-lymphocyte functions during early syphilitic infection are complex. Infect Immun 59:4180-6
Tomai, M A; Fitzgerald, T J (1991) Splenic macrophage function in early syphilitic infection is complex. Stimulation versus down-regulation. J Immunol 146:3171-6
Fitzgerald, T J; Tomai, M A; Trachte, G J et al. (1991) Prostaglandins in experimental syphilis: treponemes stimulate adherent spleen cells to secrete prostaglandin E2, and indomethacin upregulates immune functions. Infect Immun 59:143-9
Fitzgerald, T J (1991) Syphilis vaccine: up-regulation of immunogenicity by cyclophosphamide, Ribi adjuvant, and indomethacin confers significant protection against challenge infection in rabbits. Vaccine 9:266-72
Fitzgerald, T J; Elmquist, B J (1990) Soluble factors from rabbit spleen cells kill and lyse Treponema pallidum in vitro. Can J Microbiol 36:711-7
Tomai, M A; Elmquist, B J; Warmka, S M et al. (1989) Macrophage-mediated suppression of con A-induced IL-2 production in spleen cells from syphilitic rabbits. J Immunol 143:309-14
Fitzgerald, T J (1987) Activation of the classical and alternative pathways of complement by Treponema pallidum subsp. pallidum and Treponema vincentii. Infect Immun 55:2066-73

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