Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI019350-11
Application #
2060914
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1982-09-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Adderson, E E; Shackelford, P G; Carroll, W L (1998) Somatic hypermutation in T-independent and T-dependent immune responses to Haemophilus influenzae type b polysaccharide. Clin Immunol Immunopathol 89:240-6
Adderson, E E; Wilson, P M; Cunningham, M W et al. (1998) Haemophilus influenzae type b polysaccharides-protein conjugate vaccine elicits a more diverse antibody repertoire in infants than in adults. J Immunol 161:4177-82
Granoff, D M; Shackelford, P G; Holmes, S J et al. (1993) Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates. Description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avid J Clin Invest 91:788-96
Adderson, E E; Azmi, F H; Wilson, P M et al. (1993) The human VH3b gene subfamily is highly polymorphic. J Immunol 151:800-9
Adderson, E E; Shackelford, P G; Insel, R A et al. (1992) Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations. J Clin Invest 89:729-38
Adderson, E E; Shackelford, P G; Quinn, A et al. (1991) Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide. J Immunol 147:1667-74
Shackelford, P G; Granoff, D M; Madassery, J V et al. (1990) Clinical and immunologic characteristics of healthy children with subnormal serum concentrations of IgG2. Pediatr Res 27:16-21
Granoff, D M; Suarez, B K; Pandey, J P et al. (1988) Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine. J Infect Dis 157:1142-9
Shackelford, P G; Granoff, D M (1988) IgG subclass composition of the antibody response of healthy adults, and normal or IgG2-deficient children to immunization with H. influenzae type b polysaccharide vaccine or Hib PS-protein conjugate vaccines. Monogr Allergy 23:269-81
Gresham, H D; McGarr, J A; Shackelford, P G et al. (1988) Studies on the molecular mechanisms of human Fc receptor-mediated phagocytosis. Amplification of ingestion is dependent on the generation of reactive oxygen metabolites and is deficient in polymorphonuclear leukocytes from patients with chronic granulomat J Clin Invest 82:1192-201

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