The epoxytrichothecenes are a group of fungal metabolites which possess antibiotic, antifungal, antiviral, phytotoxic, and/or cytotoxic properties. Members of this family are promising leads for the development of anticancer agents. We propose herein to develop stereospecific syntheses of anguidine and various macrocyclic derivatives of verrucarol including verrucarins A and B, roridins A, D, and E, and baccharin. These projects are extensions of our work on verrucarol and verrucarin J. syntheses of which were completed in the first three years of this grant. Considerable progress towards the synthesis of verrucarins A, B, and the roridins was also realized in the preceding grant period. Completion of these syntheses will make possible the synthesis of a large number of epoxytrichothecenes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020779-06
Application #
3130606
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-01-01
Project End
1986-12-31
Budget Start
1986-09-01
Budget End
1986-12-31
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139