The presence of dogs with selective IgA deficiency has been documented in a large Beagle breeding kennel. This is an unique spontaneous animal model with clinical and immunologic findings similar to that of selective IgA deficiency in man, the most common human primary immunodeficiency. The disease in the dog is characterized by chronic, recurrent respiratory infections, dermatitis, and possibly gastrointestinal infections low concentrations of serum IgA, and normal concentrations of IgG and IgM; normal T cell function as measured by lymphocyte transformation tests; the presence of autoantibodies; and a defect in the terminal differentiation of IgA B cells into IgA secreting plasma cells. This animal model may prove useful in addressing some of the important questions which remain to be answered concerning human selective IgA deficiency. The underlying immunologic defect in man is not fully defined nor has the mode of inheritance been well defined. Another current point of controversy is the role of a """"""""true"""""""" IgA deficiency and low IgA concentrations in the manifestation of clinical disease.
These specific aims of this proposal are: 1. To develop a breeding colony of IgA deficient dogs from animals we have already identified at the kennel. 2. To define the mode of interitance of selective IgA deficiency in these dogs. 3. To determine the cellular defect(s) in selective IgA deficiency in this population. 4. To define the relationship of selective IgA deficiency, and the severity of the deficiency, to clinical infections of the respiratory tract, gastrointestinal tract and skin. 5. To define the relationship of selective IgA deficiency, and the severity of the deficiency, to atopic and autoimmune disease. 6. To develop and evaluate modes of therapeutic intervention in selective IgA deficiency.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020860-02
Application #
3130658
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Veterinary Medicine
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
HogenEsch, H; Felsburg, P J (1992) Isolation and phenotypic and functional characterization of cells from Peyer's patches in the dog. Vet Immunol Immunopathol 31:1-10
HogenEsch, H; Felsburg, P J (1992) Immunohistology of Peyer's patches in the dog. Vet Immunol Immunopathol 30:147-60
Daniel, S L; Ogilvie, G K; Felsburg, P J (1990) Modulation of canine lymphocyte blastogenesis via histamine. Vet Immunol Immunopathol 24:69-77
Shofer, F S; Glickman, L T; Payton, A J et al. (1990) Influence of parental serum immunoglobulins on morbidity and mortality of beagles and their offspring. Am J Vet Res 51:239-44
HogenEsch, H; Felsburg, P J (1990) Ultrastructure and alkaline phosphatase activity of the dome epithelium of canine Peyer's patches. Vet Immunol Immunopathol 24:177-86
Wunderli, P S; Felsburg, P J (1989) An improved method for the isolation of enriched canine peripheral blood mononuclear cell and peripheral blood lymphocyte preparations. Vet Immunol Immunopathol 20:335-44
Hogenesch, H; Felsburg, P J (1989) Development and functional characterization of T cell lines from canine Peyer's patches. Vet Immunol Immunopathol 23:29-39
Glickman, L T; Shofer, F S; Payton, A J et al. (1988) Survey of serum IgA, IgG, and IgM concentrations in a large beagle population in which IgA deficiency had been identified. Am J Vet Res 49:1240-5
Felsburg, P J; Glickman, L T; Shofer, F et al. (1987) Clinical, immunologic and epidemiologic characteristics of canine selective IgA deficiency. Adv Exp Med Biol 216B:1461-70
HogenEsch, H; Housman, J M; Felsburg, P J (1987) Canine Peyer's patches: macroscopic, light microscopic, scanning electron microscopic and immunohistochemical investigations. Adv Exp Med Biol 216A:249-56