The long-range goal of this project is to understand the mechanism whereby the bacterial cell localizes the site of cell division and to define the subsequent changes in organization of the cell envelope that result in formation of the division septum at this site. A combination of genetic, electron microscopic and membrane isolation techniques will be used to study events that precede visible ingrowth of the septum. An attempt will be made to identify genes responsible for progression through the early stages of differentiation at division sites, to describe the biogenesis of pre-septation structures by studying synchronized cells and appropriate cello division mutants, and to define the relationship of these structures to other division-related events.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022183-05
Application #
3132986
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1985-03-01
Project End
1990-02-28
Budget Start
1989-03-01
Budget End
1990-02-28
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Type
School of Medicine & Dentistry
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030