Abstract

These investigations will analyze the effectiveness of lectin fractionated haploidentical parental or sibling marrow transplants in treatment of severe combined immunodeficiency or acute leukemia in man. If these investigations prove favorable, this approach will be extended to treatment of other highly lethal hematological and immunodeficiency diseases of man. Bone marrow transplantation in mice will also be investigated as a means to introduce resistance genes for the prevention of AKR leukemia or against the development of Potter myelomas in inbred mice and to prevent and treat autoimmune disease in NZB, NZBx NZW and other autoimmune-prone mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022360-05
Application #
3133346
Study Section
Immunobiology Study Section (IMB)
Project Start
1984-09-30
Project End
1990-11-30
Budget Start
1988-12-01
Budget End
1990-11-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of South Florida
Department
Type
Schools of Medicine
DUNS #
City
Tampa
State
FL
Country
United States
Zip Code
33612

  Publications

Sugiura, K; Inaba, M; Hisha, H et al. (1997) Requirement of major histocompatibility complex-compatible microenvironment for spleen colony formation (CFU-S on day 12 but not on day 8). Stem Cells 15:461-8
Iwai, H; Day, N K; Hamada, N et al. (1994) Bone marrow transplantation therapy using resistant donors for retrovirus-induced leukaemia in mice. Clin Exp Immunol 95:135-40
Gengozian, N; Good, R A; Fu, S M (1992) Development and characterization of monoclonal antibodies to lymphocyte cell surface antigens of the rhesus monkey. Transplantation 53:1306-12
Arase, H; Arase, N; Ogasawara, K et al. (1992) Clonal elimination of self reactive V beta 6+ T cells induced by H-2 products expressed on thymic radio-resistant components. Int Immunol 4:75-82
Sugiura, K; Ikehara, S; Inaba, M et al. (1992) Enrichment of murine bone marrow natural suppressor activity in the fraction of hematopoietic progenitors with interleukin 3 receptor-associated antigen. Exp Hematol 20:256-63
Ogasawara, K; Naruse, H; Itoh, Y et al. (1992) A strategy for making synthetic peptide vaccines. Proc Natl Acad Sci U S A 89:8995-9
Gengozian, N; Moriarty, C; Good, R A (1992) Functional evaluation of T helper, T suppressor, and B lymphocytes in lethally irradiated rhesus monkeys injected with autologous bone marrow. Transplantation 53:1313-22
Sugiura, K; Yasumizu, R; Iwai, H et al. (1991) Long-term immunologic tolerance induction in chimeric mice after bone marrow transplantation across major histocompatibility barriers: persistent or redeveloping immunologic responsiveness after prolonged survival. Thymus 18:137-53
Iwabuchi, C; Iwabuchi, K; Kobayashi, S et al. (1991) Deficiency in early development of the thymus-dependent cells in irradiation chimeras attributable to recipient's environment. J Immunol 146:26-34
Gengozian, N; Hill, R J; Good, R A et al. (1991) Two populations of guinea pig erythrocyte-rosetting cells in the cat: evidence for their T-helper function in mitogen-induced synthesis of Ig and interleukin-2. Cell Immunol 133:1-14

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