The objective of this proposal is to characterize the transmission of the putative AIDS agent (HTLV III) in the sexual partners and children of Haitian AIDS patients and to determine the natural history of the infection in the affected family members. We will determine the prevalence of HTLV III seropositivity, and seroconversion rates in the sexual partners and children. We will compare and contrast the AIDs families with similar studies of age-sex matched friends of the AIDS sexual partner. The children of these friends will serve as controls for the children of the AIDS families. HTLV III seropositive subjects (children and adults) will be followed for periods of 1-4 years to determine the natural history of this infection. Evidence for vertical and horizontal infection within families will be sought. HTLV III viral isolation studies of pregnant women and young children will assist in this determination. We will examine sexual and non-sexual activities of the study subjects to determine if particular activities are associated with acquisition of HTLV III infection or influence the natural history of the infection.
| Deschamps, M M; Johnson Jr, W D; Pape, J W (1994) Feasibility and cohort development for HIV vaccine trials in Haiti. AIDS Res Hum Retroviruses 10 Suppl 2:S231-3 |
| Landay, A; Ho, J L; Hom, D et al. (1993) A rapid manual method for CD4+ T-cell quantitation for use in developing countries. AIDS 7:1565-8 |
| Pape, J W; Deschamps, M M; Verdier, R I et al. (1992) The urge for an AIDS vaccine: perspectives from a developing country. AIDS Res Hum Retroviruses 8:1535-7 |
| Pape, J W; Stanback, M E; Pamphile, M et al. (1990) Prevalence of HIV infection and high-risk activities in Haiti. J Acquir Immune Defic Syndr 3:995-1001 |
| Pape, J W; Verdier, R I; Johnson Jr, W D (1989) Treatment and prophylaxis of Isospora belli infection in patients with the acquired immunodeficiency syndrome. N Engl J Med 320:1044-7 |
| Johnson Jr, W D; Pape, J W (1989) AIDS in Haiti. Immunol Ser 44:65-78 |
| Liautaud, B; Pape, J W; DeHovitz, J A et al. (1989) Pruritic skin lesions. A common initial presentation of acquired immunodeficiency syndrome. Arch Dermatol 125:629-32 |
| Deschamps, M M; Pape, J W; Verdier, R I et al. (1988) Treatment of candida esophagitis in AIDS patients. Am J Gastroenterol 83:20-1 |
| Pape, J W; Levine, E; Beaulieu, M E et al. (1987) Cryptosporidiosis in Haitian children. Am J Trop Med Hyg 36:333-7 |
| DeHovitz, J A; Pape, J W; Boncy, M et al. (1986) Clinical manifestations and therapy of Isospora belli infection in patients with the acquired immunodeficiency syndrome. N Engl J Med 315:87-90 |
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