The effects of recombinant human interleukin-1 (IL-1) on the release of prostaglandins (PG) from dermal fibroblasts and rabbit brain tissue will be studied. Specifically, three main topics will be investigated: a. the effects (i.e. time course) of IL-1 on the release of PG from fibroblasts and rabbit brain tissue. b. the nature of the interaction of isotopically-labeled IL-1 with its receptor on fibroblasts c. the role of Ca++ and regulatory phosphoinositides on the IL-I - induced release of PG from fibroblasts. The above experiments will utilize, for the first time, recombinant IL-1. Data derived from this grant will supply additional information about the inflammatory response and provide details about how IL-1 may exert some of its immunologic and inflammatory effects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023164-03
Application #
3135052
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1986-01-01
Project End
1988-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Arts and Sciences
DUNS #
073134835
City
Medford
State
MA
Country
United States
Zip Code
02155