Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023524-04
Application #
3135766
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1986-03-01
Project End
1991-02-28
Budget Start
1989-03-01
Budget End
1990-02-28
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101
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