The objectives of this proposal are to study the cellular proteins which mediate cell attachment of the mammalian reovirus type 3. Through the study of the viral binding protein (receptor), we hope to better understand the processes of viral infectivity and pathogenesis and the potential roles and effects of receptor modulation on these processes. We will characterize the similarities of the reovirus to the mammalian beta-adrenergic receptor.
| Yui, K; Hashimoto, Y; Greene, M I (1988) T cell receptors of autoimmune mice: functional and molecular analysis of novel T cell subsets in C3H-gld/gld mice. Immunol Res 7:173-88 |
| Yui, K; Hashimoto, Y; Wadsworth, S et al. (1987) Characterization of Lyt-2-, L3T4- class I-specific cytolytic clones in C3H-gld/gld mice. Implications for functions of accessory molecules and programmed development. J Exp Med 166:1026-40 |
