Abstract

This proposal concerns a 4-year systematic vaccine development program utilizing 4 naturally occurring retrovirus diseases, feline leukemia virus (FeLV) infection of domestic cats, simian-AIDS retrovirus, type 1 (SRV-1) and Sooty mangabey lentivirus (SMLV) infections of rhesus monkeys, and caprine arthritis-encephalitis virus (CAEV) infection of dairy goats. The main objective of the project is to compare the effectiveness of proven and unproven vaccine strategies on a diverse group of animal retroviral diseases. In keeping with our previous research approaches, studies will begin with conventional inactivated whole virus vaccines, followed by native envelope glycoprotein, recombinant/subunit envelope protein, synthetic peptide, genetically engineered vaccinia virus, and anti-idiotype antibody vaccines. The vaccine strategies applied to each of the retrovirus infections varies according to the amount of background research already completed in that system. Anti-idiotype antibody vaccines will be tested in the FeLV system, because conventional and molecular-genetic approaches have already been tested. Research on inactivated whole SRV-1 vaccines has already been completed, so work on this disease will be directed to native envelope-glycoprotein, recombinant/subunit, synthetic peptide, genetically altered vaccinia virus, and anti-idiotype antibody vaccines. Work on SMLV and CAEV infections will be more developmental and directed at basic pathogenesis and inactivated whole virus vaccines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI024292-02
Application #
3137191
Study Section
(SRC)
Project Start
1986-09-01
Project End
1990-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618