Synthesis of Catalytic Antibodies

Agency: National Institute of Health (NIH)
Institute: National Institute of Allergy and Infectious Diseases (NIAID)
Type: Research Project (R01)
Project #: 5R01AI024695-10
Application #: 2062686
Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)


NIH 1996 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1995 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1994 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1993 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1992 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1991 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1990 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1989 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1988 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley
NIH 1987 R01 AI	Synthesis of Catalytic Antibodies Schultz, Peter G. / University of California Berkeley

Romesberg, F E; Schultz, P G (1999) A mutational study of a Diels-Alderase catalytic antibody. Bioorg Med Chem Lett 9:1741-4

Pedersen, H; Holder, S; Sutherlin, D P et al. (1998) A method for directed evolution and functional cloning of enzymes. Proc Natl Acad Sci U S A 95:10523-8

Romesberg, F E; Santarsiero, B D; Spiller, B et al. (1998) Structural and kinetic evidence for strain in biological catalysis. Biochemistry 37:14404-9

Hsieh-Wilson, L C; Schultz, P G; Stevens, R C (1996) Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. Proc Natl Acad Sci U S A 93:5363-7

Jacobsen, J R; Schultz, P G (1995) The scope of antibody catalysis. Curr Opin Struct Biol 5:818-24

Jacobsen, J R; Schultz, P G (1994) Antibody catalysis of peptide bond formation. Proc Natl Acad Sci U S A 91:5888-92

Lesley, S A; Patten, P A; Schultz, P G (1993) A genetic approach to the generation of antibodies with enhanced catalytic activities. Proc Natl Acad Sci U S A 90:1160-5

Jacobsen, J R; Prudent, J R; Kochersperger, L et al. (1992) An efficient antibody-catalyzed aminoacylation reaction. Science 256:365-7

Pollack, S J; Nakayama, G R; Schultz, P G (1988) Introduction of nucleophiles and spectroscopic probes into antibody combining sites. Science 242:1038-40