Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI024695-10
Application #
2062686
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1987-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Romesberg, F E; Schultz, P G (1999) A mutational study of a Diels-Alderase catalytic antibody. Bioorg Med Chem Lett 9:1741-4
Romesberg, F E; Santarsiero, B D; Spiller, B et al. (1998) Structural and kinetic evidence for strain in biological catalysis. Biochemistry 37:14404-9
Pedersen, H; Holder, S; Sutherlin, D P et al. (1998) A method for directed evolution and functional cloning of enzymes. Proc Natl Acad Sci U S A 95:10523-8
Hsieh-Wilson, L C; Schultz, P G; Stevens, R C (1996) Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. Proc Natl Acad Sci U S A 93:5363-7
Jacobsen, J R; Schultz, P G (1995) The scope of antibody catalysis. Curr Opin Struct Biol 5:818-24
Jacobsen, J R; Schultz, P G (1994) Antibody catalysis of peptide bond formation. Proc Natl Acad Sci U S A 91:5888-92
Lesley, S A; Patten, P A; Schultz, P G (1993) A genetic approach to the generation of antibodies with enhanced catalytic activities. Proc Natl Acad Sci U S A 90:1160-5
Jacobsen, J R; Prudent, J R; Kochersperger, L et al. (1992) An efficient antibody-catalyzed aminoacylation reaction. Science 256:365-7
Pollack, S J; Nakayama, G R; Schultz, P G (1988) Introduction of nucleophiles and spectroscopic probes into antibody combining sites. Science 242:1038-40
Schultz, P G (1988) The interplay between chemistry and biology in the design of enzymatic catalysts. Science 240:426-33