Function of Nef Gene in HIV Replication and Pathogenesis

Cheng-Mayer, Cecilia C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 3R01AI025284-07S1
• Application #: 3138696
• Study Section: Special Emphasis Panel (ARR (V1))
• Project Start: 1987-09-01
• Project End: 1994-06-30
• Budget Start: 1993-06-01
• Budget End: 1994-06-30
• Support Year: 7
• Fiscal Year: 1994

Institution

• Name: University of California San Francisco
• Type: Schools of Medicine
• DUNS #: 073133571
• City: San Francisco
• State: CA
• Country: United States
• Zip Code: 94143

Publications

Sawai, E T; Baur, A S; Peterlin, B M et al. (1995) A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J Biol Chem 270:15307-14

LeGuern, M; Shioda, T; Levy, J A et al. (1993) Single amino acid change in Tat determines the different rates of replication of two sequential HIV-1 isolates. Virology 195:441-7

Cheng-Mayer, C; Shioda, T; Levy, J A (1991) Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120. J Virol 65:6931-41

Cheng-Mayer, C; Seto, D; Levy, J A (1991) Altered host range of HIV-1 after passage through various human cell types. Virology 181:288-94

Levy, J A (1991) Viral and cellular factors influencing HIV tropism. Adv Exp Med Biol 300:1-15

York-Higgins, D; Cheng-Mayer, C; Bauer, D et al. (1990) Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome. J Virol 64:4016-20

Cheng-Mayer, C; Iannello, P; Shaw, K et al. (1989) Differential effects of nef on HIV replication: implications for viral pathogenesis in the host. Science 246:1629-32

Cheng-Mayer, C; Seto, D; Tateno, M et al. (1988) Biologic features of HIV-1 that correlate with virulence in the host. Science 240:80-2