Model of X-Linked Severe Combined Immnunodeficiency

Felsburg, Peter J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI026103-03
• Application #: 3139718
• Study Section: Immunological Sciences Study Section (IMS)
• Project Start: 1990-04-01
• Project End: 1992-07-31
• Budget Start: 1992-04-01
• Budget End: 1992-07-31
• Support Year: 3
• Fiscal Year: 1992

Institution

• Name: Purdue University
• Type: Schools of Veterinary Medicine
• DUNS #: 072051394
• City: West Lafayette
• State: IN
• Country: United States
• Zip Code: 47907

Publications

Felsburg, P J (2002) Overview of immune system development in the dog: comparison with humans. Hum Exp Toxicol 21:487-92

Hartnett, B J; Somberg, R L; Krakowka, S et al. (2000) B-cell function in canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol 75:121-34

Hartnett, B J; Henthorn, P S; Moore, P F et al. (1999) Bone marrow transplantation for canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol 69:137-44

Felsburg, P J; Hartnett, B J; Henthorn, P S et al. (1999) Canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol 69:127-35

Felsburg, P J; Somberg, R L; Hartnett, B J et al. (1997) Full immunologic reconstitution following nonconditioned bone marrow transplantation for canine X-linked severe combined immunodeficiency. Blood 90:3214-21

Somberg, R L; Tipold, A; Hartnett, B J et al. (1996) Postnatal development of T cells in dogs with X-linked severe combined immunodeficiency. J Immunol 156:1431-5

Somberg, R L; Pullen, R P; Casal, M L et al. (1995) A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Vet Immunol Immunopathol 47:203-13

Henthorn, P S; Somberg, R L; Fimiani, V M et al. (1994) IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease. Genomics 23:69-74

Somberg, R L; Robinson, J P; Felsburg, P J (1994) T lymphocyte development and function in dogs with X-linked severe combined immunodeficiency. J Immunol 153:4006-15

Felsburg, P J; Somberg, R L; Krakowka, G S (1994) Acute monocytic leukemia in a dog with X-linked severe combined immunodeficiency. Clin Diagn Lab Immunol 1:379-84