Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI026542-02
Application #
3140307
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1989-04-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Michigan State University
Department
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Kierszenbaum, F; Majumder, S; Paredes, P et al. (1998) The Trypanosoma cruzi immunosuppressive factor (TIF) targets a lymphocyte activation event subsequent to increased intracellular calcium ion concentration and translocation of protein kinase C but previous to cyclin D2 and cdk4 mRNA accumulation. Mol Biochem Parasitol 92:133-45
Kierszenbaum, F; Lopez, H M; Sztein, M B (1996) Trypanosoma cruzi downregulates the production of interleukin-2, interferon-gamma, interleukin-4 and interleukin-5 by activated human lymphocytes. J Parasitol 82:652-6
Kierszenbaum, F; Majumder, S; Mejia Lopez, H et al. (1995) Differential effects of Trypanosoma cruzi on the transcription of the p55IL-2R, c-fos, c-myc and CD69 genes in activated human lymphocytes. Parasite Immunol 17:197-205
Kierszenbaum, F; Mejia Lopez, H; Tanner, M K et al. (1995) Trypanosoma cruzi-induced decrease in the level of interferon-gamma receptor expression by resting and activated human blood lymphocytes. Parasite Immunol 17:207-14
Kierszenbaum, F; Lopez, H M; Sztein, M B (1994) Inhibition of Trypanosoma cruzi-specific immune responses by a protein produced by T. cruzi in the course of Chagas' disease. Immunology 81:462-7
Kierszenbaum, F; Moretti, E; Sztein, M B (1993) Molecular basis of Trypanosoma cruzi-induced immunosuppression. Altered expression by activated human lymphocytes of molecules which regulate antigen recognition and progression through the cell cycle. Biol Res 26:197-207
Kierszenbaum, F; Mejia Lopez, H; Sztein, M B (1993) Does interleukin-2 restore lymphocyte responses suppressed by Trypanosoma cruzi? Immunology 80:445-50
Lopez, H M; Tanner, M K; Kierszenbaum, F et al. (1993) Alterations induced by Trypanosoma cruzi in activated mouse lymphocytes. Parasite Immunol 15:273-80
Sztein, M B; Kierszenbaum, F (1992) Suppression by Trypanosoma cruzi of T-cell receptor expression by activated human lymphocytes. Immunology 77:277-83
Kierszenbaum, F; Sztein, M B (1992) Trypanosoma cruzi suppresses the expression of the p75 chain of interleukin-2 receptors on the surface of activated helper and cytotoxic human lymphocytes. Immunology 75:546-9

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