Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI027214-01
Application #
3141377
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Fu, X T; Saibara, T; Karr, R W et al. (1996) Substitutions in the HLA-DR alpha chain differentially affect DR7-restricted T-cell recognition of rabies virus antigen. Hum Immunol 45:111-6
Hammer, J; Gallazzi, F; Bono, E et al. (1995) Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J Exp Med 181:1847-55
Fu, X T; Bono, C P; Woulfe, S L et al. (1995) Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide. J Exp Med 181:915-26
McNicholl, J M; Whitworth, W C; Oftung, F et al. (1995) Structural requirements of peptide and MHC for DR(alpha, beta 1*0401)-restricted T cell antigen recognition. J Immunol 155:1951-63
Geluk, A; Fu, X T; van Meijgaarden, K E et al. (1994) T cell receptor and peptide-contacting residues in the HLA-DR17(3) beta 1 chain. Eur J Immunol 24:3241-4
Tuosto, L; Karr, R W; Fu, X T et al. (1994) Different regions of the N-terminal domains of HLA-DR1 influence recognition of individual peptide-DR1 complexes. Hum Immunol 40:312-22
McKinney, J S; Fu, X T; Swearingen, C et al. (1994) Individual effects of the DR11-variable beta-chain residues 67, 71, and 86 upon DR(alpha,beta 1*1101)-restricted, peptide-specific T cell proliferation. J Immunol 153:5564-71
Olson, R R; Reuter, J J; McNicholl, J et al. (1994) Acidic residues in the DR beta chain third hypervariable region are required for stimulation of a DR(alpha, beta 1*0402)-restricted T-cell clone. Hum Immunol 41:193-200
Panina-Bordignon, P; Fu, X T; Lanzavecchia, A et al. (1992) Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen. J Exp Med 176:1779-84
Fu, X T; Klohe, E; Alber, C et al. (1992) Diverse locations of amino acids in HLA-DR beta chains involved in polymorphic antibody binding epitopes on DR(alpha, beta 1*0101), DR(alpha, beta 1*1101), and DR(alpha,beta 3*0202) molecules. Hum Immunol 33:193-201

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