Molecular Approaches to Anti-AIDS Drug Development

Kalman, Thomas I.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI027251-06
• Application #: 2063779
• Study Section: AIDS and Related Research Study Section 4 (ARRD)
• Project Start: 1989-04-01
• Project End: 1997-11-30
• Budget Start: 1995-12-01
• Budget End: 1997-11-30
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: State University of New York at Buffalo
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 038633251
• City: Buffalo
• State: NY
• Country: United States
• Zip Code: 14260

Publications

Jiang, Xiang-Jun; Kalman, Thomas I (2004) Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine. Nucleosides Nucleotides Nucleic Acids 23:307-16

Abraham, T W; Kalman, T I; McIntee, E J et al. (1996) Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. J Med Chem 39:4569-75

Kerr, S G; Kalman, T I (1994) N4-(dialkylamino)methylene derivatives of 2'-deoxycytidine and arabinocytidine: physicochemical studies for potential prodrug applications. J Pharm Sci 83:582-6

Kerr, S G; Kalman, T I (1992) Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analogue 2',3'-dideoxycytidine and its 3'-fluoro derivative. J Med Chem 35:1996-2001