Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI027828-05
Application #
2064123
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1991-04-01
Project End
1997-06-30
Budget Start
1995-04-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Padigel, Udaikumar M; Farrell, Jay P (2005) Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells. J Immunol 174:6340-5
Padigel, Udaikumar M; Alexander, James; Farrell, Jay P (2003) The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. J Immunol 171:3705-10
Padigel, Udaikumar M; Farrell, Jay P (2003) CD40-CD40 ligand costimulation is not required for initiation and maintenance of a Th1-type response to Leishmania major infection. Infect Immun 71:1389-95
Padigel, Udaikumar M; Kim, Nacksung; Choi, Yongwon et al. (2003) TRANCE-RANK costimulation is required for IL-12 production and the initiation of a Th1-type response to Leishmania major infection in CD40L-deficient mice. J Immunol 171:5437-41
Compton, Helen L; Farrell, Jay P (2002) CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major. J Immunol 168:1302-8
Li, Jian; Padigel, Udaikumar M; Scott, Phillip et al. (2002) Combined treatment with interleukin-12 and indomethacin promotes increased resistance in BALB/c mice with established Leishmania major infections. Infect Immun 70:5715-20
Murphy, M L; Wille, U; Villegas, E N et al. (2001) IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol 31:2848-56
Padigel, U M; Perrin, P J; Farrell, J P (2001) The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation. J Immunol 167:5874-9
Fields, P A; Armstrong, E; Hagstrom, J N et al. (2001) Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice. Gene Ther 8:354-61
Li, J; Hunter, C A; Farrell, J P (1999) Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J Immunol 162:974-9

Showing the most recent 10 out of 20 publications