Seven stereoisomers of the potential anti-HIV drug """"""""Castanospermine"""""""" (1) will be synthesized via sequences which begin with new enzyme-catalyzed reactions. These preparations are designed to be: (i) cheap and amenable to large scale production, and: (ii) asymmetric, providing either enantiomer of the product. Samples of the compounds produced will be screened for anti-HIV activity and for inhibition of glycosidases (See Appendices). Structure-activity relationships for epimers of Castanospermine are as follows: 1-Epicastanospermine, 8a-Epicastanospermine, 1.7- Diepicastanospermine, 7.8a-Diepicastanospermine, 1.8a- Diepicastanospermine, S.s-Diepicastanospermine, and 7- Epicastanospermine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028204-02
Application #
3142521
Study Section
Special Emphasis Panel (ARR (V1))
Project Start
1989-03-01
Project End
1992-02-29
Budget Start
1990-03-01
Budget End
1991-02-28
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rice University
Department
Type
Schools of Arts and Sciences
DUNS #
050299031
City
Houston
State
TX
Country
United States
Zip Code
77005