Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI028835-07
Application #
2064661
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1990-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tulane University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Ryan, E T; Crean, T I; John, M et al. (1999) In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae. Infect Immun 67:1694-701
Freytag, L C; Clements, J D (1999) Bacterial toxins as mucosal adjuvants. Curr Top Microbiol Immunol 236:215-36
Chong, C; Friberg, M; Clements, J D (1998) LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp. Vaccine 16:732-40
Toebe, C S; Clements, J D; Cardenas, L et al. (1997) Evaluation of immunogenicity of an oral Salmonella vaccine expressing recombinant Plasmodium berghei merozoite surface protein-1. Am J Trop Med Hyg 56:192-9
Bost, K L; Clements, J D (1997) Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages. Infect Immun 65:3186-92
Guidry, J J; Cardenas, L; Cheng, E et al. (1997) Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin. Infect Immun 65:4943-50
Bost, K L; Holton, R H; Cain, T K et al. (1996) In vivo treatment with anti-interleukin-13 antibodies significantly reduces the humoral immune response against an oral immunogen in mice. Immunology 87:633-41
Kincy-Cain, T; Clements, J D; Bost, K L (1996) Endogenous and exogenous interleukin-12 augment the protective immune response in mice orally challenged with Salmonella dublin. Infect Immun 64:1437-40
Chong, C; Bost, K L; Clements, J D (1996) Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect Immun 64:1154-60
Bost, K L; Clements, J D (1995) In vivo induction of interleukin-12 mRNA expression after oral immunization with Salmonella dublin or the B subunit of Escherichia coli heat-labile enterotoxin. Infect Immun 63:1076-83

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