Hemoglobin Catabolism by Plasmodium Falciparum

Cerami, Anthony

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 3R01AI030660-03S1
• Application #: 3145748
• Study Section: Tropical Medicine and Parasitology Study Section (TMP)
• Project Start: 1992-09-01
• Project End: 1996-05-31
• Budget Start: 1992-09-01
• Budget End: 1993-05-31
• Support Year: 3
• Fiscal Year: 1992

Institution

• Name: Picower Institute for Medical Research
• City: Manhasset
• State: NY
• Country: United States
• Zip Code: 11030

Publications

Martiney, J A; Ferrer, A S; Cerami, A et al. (1999) Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for chloride-dependent ionic regulation. Novartis Found Symp 226:265-77;discussion 277-80

Roepe, P D; Martiney, J A (1999) Are ion-exchange processes central to understanding drug-resistance phenomena? Trends Pharmacol Sci 20:62-5

Paciorkowski, A; Dai, W W; Cerami, A et al. (1997) Synergism of cimetidine with anti-malarial agents. J Parasitol 83:960-3

Martiney, J A; Cerami, A; Slater, A F (1996) Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait. Mol Med 2:236-46

Berger, B J; Martiney, J; Slater, A F et al. (1995) Chloroquine resistance is not associated with drug metabolism in Plasmodium falciparum. J Parasitol 81:1004-8

Martiney, J A; Cerami, A; Slater, A F (1995) Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J Biol Chem 270:22393-8