Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030742-05
Application #
2065867
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-01-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Smith, R M; Connor, J A; Chen, L M et al. (1996) The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase. J Clin Invest 98:977-83
Gottlieb, R A; Giesing, H A; Engler, R L et al. (1995) The acid deoxyribonuclease of neutrophils: a possible participant in apoptosis-associated genome destruction. Blood 86:2414-8
Gottlieb, R A; Giesing, H A; Zhu, J Y et al. (1995) Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase. Proc Natl Acad Sci U S A 92:5965-8
Park, J W; Benna, J E; Scott, K E et al. (1994) Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol. Biochemistry 33:2907-11
el Benna, J; Ruedi, J M; Babior, B M (1994) Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase J Biol Chem 269:6729-34
el Benna, J; Faust, L P; Babior, B M (1994) The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem 269:23431-6
Park, J W; Babior, B M (1993) Effects of diacylglycerol on the activation and kinetics of the respiratory burst oxidase in a cell-free system from human neutrophils: evidence that diacylglycerol may regulate nucleotide uptake by a GTP-binding protein. Arch Biochem Biophys 306:119-24
Foroozan, R; Ruedi, J M; Babior, B M (1992) The reduction of cytochrome b558 and the activity of the respiratory burst oxidase from human neutrophils. J Biol Chem 267:24400-7
Babior, B M (1992) The respiratory burst oxidase. Adv Enzymol Relat Areas Mol Biol 65:49-95
Umei, T; Babior, B M; Curnutte, J T et al. (1991) Identification of the NADPH-binding subunit of the respiratory burst oxidase. J Biol Chem 266:6019-22