Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI030882-06
Application #
2065958
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1990-12-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Joyce, G F (2001) RNA cleavage by the 10-23 DNA enzyme. Methods Enzymol 341:503-17
Sheppard, T L; Ordoukhanian, P; Joyce, G F (2000) A DNA enzyme with N-glycosylase activity. Proc Natl Acad Sci U S A 97:7802-7
Santoro, S W; Joyce, G F (1998) Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry 37:13330-42
Tsang, J; Joyce, G F (1996) Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution. J Mol Biol 262:31-42
Tsang, J; Joyce, G F (1996) In vitro evolution of randomized ribozymes. Methods Enzymol 267:410-26
Raillard, S A; Joyce, G F (1996) Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme. Biochemistry 35:11693-701
Breaker, R R; Joyce, G F (1994) Emergence of a replicating species from an in vitro RNA evolution reaction. Proc Natl Acad Sci U S A 91:6093-7
Tsang, J; Joyce, G F (1994) Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. Biochemistry 33:5966-73
Beaudry, A A; Joyce, G F (1992) Directed evolution of an RNA enzyme. Science 257:635-41
Cadwell, R C; Joyce, G F (1992) Randomization of genes by PCR mutagenesis. PCR Methods Appl 2:28-33