Abstract

The goal of this study is to improve understanding and management of postinfectious chronic fatigue. The first specific aim is to determine whether post Lyme syndrome (PLS) is antibiotic-responsive. The second is to determine whether cerebrospinal fluid (CSF) markers in these patients predict treatment response.
The third aim i s to determine whether premorbid psychosocial factors predict poor treatment outcome. Post treatment Lyme syndrome patients (N=50) will be evaluated at entry for fatigue, CSF and cognitive disturbances. Patients will be randomized to receive four weeks of intravenous ceftriaxone or placebo treatment. Patients will be re-evaluated at one month post treatment for fatigue response, and at six months post treatment for fatigue, CSF and cognitive response.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031561-06
Application #
2672080
Study Section
Special Emphasis Panel (ZRG5-CFS (01))
Project Start
1992-04-01
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Neurology
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Krupp, L B; Hyman, L G; Grimson, R et al. (2003) Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology 60:1923-30
Schutzer, S E; Coyle, P K; Chen, D (2001) The role of the allergist in Lyme disease. Allergy Asthma Proc 22:29-31
Schutzer, S E; Coyle, P K; Reid, P et al. (1999) Borrelia burgdorferi-specific immune complexes in acute Lyme disease. JAMA 282:1942-6
Gaudino, E A; Coyle, P K; Krupp, L B (1997) Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences. Arch Neurol 54:1372-6
Krupp, L B; Sliwinski, M; Masur, D M et al. (1994) Cognitive functioning and depression in patients with chronic fatigue syndrome and multiple sclerosis. Arch Neurol 51:705-10
Coyle, P K; Krupp, L B; Doscher, C et al. (1994) Borrelia burgdorferi reactivity in patients with severe persistent fatigue who are from a region in which Lyme disease is endemic. Clin Infect Dis 18 Suppl 1:S24-7
Krupp, L B; Masur, D M; Kaufman, L D (1993) Neurocognitive dysfunction in the eosinophilia-myalgia syndrome. Neurology 43:931-6
Coyle, P K (1993) Neurologic complications of Lyme disease. Rheum Dis Clin North Am 19:993-1009
Coyle, P K; Krupp, L B; Doscher, C (1993) Significance of reactive Lyme serology in multiple sclerosis. Ann Neurol 34:745-7
Coyle, P K; Deng, Z; Schutzer, S E et al. (1993) Detection of Borrelia burgdorferi antigens in cerebrospinal fluid. Neurology 43:1093-8