Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI031610-04
Application #
2066598
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Lin, B; Short, S A; Eskildsen, M et al. (2001) Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(-) Escherichia coli. Biochim Biophys Acta 1499:222-31
Perides, G; Tanner-Brown, L M; Eskildsen, M A et al. (1999) Borrelia burgdorferi induces matrix metalloproteinases by neural cultures. J Neurosci Res 58:779-90
Perides, G; Charness, M E; Tanner, L M et al. (1998) Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis. J Infect Dis 177:401-8
Hu, L T; Klempner, M S (1997) Host-pathogen interactions in the immunopathogenesis of Lyme disease. J Clin Immunol 17:354-65
Hu, L T; Pratt, S D; Perides, G et al. (1997) Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi. Infect Immun 65:4989-95
Hu, L T; Perides, G; Tanner, L M et al. (1997) Detection of a 130-kD matrix metalloproteinase in cerebrospinal fluid from a patient with Lyme neuroborreliosis. Clin Infect Dis 24:1276-7
Perides, G; Noring, R; Klempner, M S (1996) Inhibition of Borrelia burgdorferi-bound fibrinolytic enzymes by alpha2-antiplasmin, PAI-1 and PAI-2. Biochem Biophys Res Commun 219:690-5
Klempner, M S; Noring, R; Epstein, M P et al. (1996) Binding of human urokinase type plasminogen activator and plasminogen to Borrelia species. J Infect Dis 174:97-104
Klempner, M S; Noring, R; Epstein, M P et al. (1995) Binding of human plasminogen and urokinase-type plasminogen activator to the Lyme disease spirochete, Borrelia burgdorferi. J Infect Dis 171:1258-65
Hu, L T; Perides, G; Noring, R et al. (1995) Binding of human plasminogen to Borrelia burgdorferi. Infect Immun 63:3491-6