Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI032056-05
Application #
2066953
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1992-02-01
Project End
1997-06-30
Budget Start
1996-02-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Leite, M F; Moyer, M S; Andrews, N W (1998) Expression of the mammalian calcium signaling response to Trypanosoma cruzi in Xenopus laevis oocytes. Mol Biochem Parasitol 92:1-13
Caler, E V; Vaena de Avalos, S; Haynes, P A et al. (1998) Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi. EMBO J 17:4975-86
Burleigh, B A; Caler, E V; Webster, P et al. (1997) A cytosolic serine endopeptidase from Trypanosoma cruzi is required for the generation of Ca2+ signaling in mammalian cells. J Cell Biol 136:609-20
Rodriguez, A; Rioult, M G; Ora, A et al. (1995) A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells. J Cell Biol 129:1263-73
Burleigh, B A; Andrews, N W (1995) A 120-kDa alkaline peptidase from Trypanosoma cruzi is involved in the generation of a novel Ca(2+)-signaling factor for mammalian cells. J Biol Chem 270:5172-80
Burleigh, B A; Andrews, N W (1995) The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu Rev Microbiol 49:175-200
Tardieux, I; Nathanson, M H; Andrews, N W (1994) Role in host cell invasion of Trypanosoma cruzi-induced cytosolic-free Ca2+ transients. J Exp Med 179:1017-22
Andrews, N W (1994) From lysosomes into the cytosol: the intracellular pathway of Trypanosoma cruzi. Braz J Med Biol Res 27:471-5
Andrews, N W (1993) Living dangerously: how Trypanosoma cruzi uses lysosomes to get inside host cells, and then escapes into the cytoplasm. Biol Res 26:65-7
Hall, B F (1993) Trypanosoma cruzi: mechanisms for entry into host cells. Semin Cell Biol 4:323-33

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