Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI032097-01A1
Application #
3147131
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-01-01
Project End
1995-12-31
Budget Start
1993-01-01
Budget End
1993-12-31
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Oklahoma Health Sciences Center
Department
Type
Schools of Dentistry
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117

  Publications

Kennedy, Catherine L; Lyras, Dena; Cordner, Leanne M et al. (2009) Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun 77:943-51
Melton-Witt, Jody A; Bentsen, Lori M; Tweten, Rodney K (2006) Identification of functional domains of Clostridium septicum alpha toxin. Biochemistry 45:14347-54
Wichroski, Michael J; Melton, Jody A; Donahue, Carolyn G et al. (2002) Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins. Infect Immun 70:4353-61
Sellman, B R; Tweten, R K (1997) The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis. Mol Microbiol 25:429-40
Gordon, V M; Benz, R; Fujii, K et al. (1997) Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun 65:4130-4
Ballard, J; Crabtree, J; Roe, B A et al. (1995) The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect Immun 63:340-4
Gottschalk, S; Tweten, R K; Smith, L C et al. (1995) Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther 2:498-503
Johnson, S; Driks, M R; Tweten, R K et al. (1994) Clinical courses of seven survivors of Clostridium septicum infection and their immunologic responses to alpha toxin. Clin Infect Dis 19:761-4
Ballard, J; Sokolov, Y; Yuan, W L et al. (1993) Activation and mechanism of Clostridium septicum alpha toxin. Mol Microbiol 10:627-34