Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI033062-04S1
Application #
2068037
Study Section
Immunobiology Study Section (IMB)
Project Start
1993-05-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Yoshida, Toshimi; Landhuis, Esther; Dose, Marei et al. (2013) Transcriptional regulation of the Ikzf1 locus. Blood 122:3149-59
Yoshida, Toshimi; Ng, Samuel Yao-Ming; Georgopoulos, Katia (2010) Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr Opin Immunol 22:154-60
Koipally, J; Georgopoulos, K (2000) Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem 275:19594-602
Koipally, J; Renold, A; Kim, J et al. (1999) Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 18:3090-100
Nichogiannopoulou, A; Trevisan, M; Neben, S et al. (1999) Defects in hemopoietic stem cell activity in Ikaros mutant mice. J Exp Med 190:1201-14
Koipally, J; Kim, J; Jones, B et al. (1999) Ikaros chromatin remodeling complexes in the control of differentiation of the hemo-lymphoid system. Cold Spring Harb Symp Quant Biol 64:79-86
Kelley, C M; Ikeda, T; Koipally, J et al. (1998) Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol 8:508-15
Wu, L; Nichogiannopoulou, A; Shortman, K et al. (1997) Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 7:483-92
Morgan, B; Sun, L; Avitahl, N et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J 16:2004-13
Sun, L; Liu, A; Georgopoulos, K (1996) Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J 15:5358-69

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