Abstract

This application is intended to test the hypothesis that the fever, fatigue and myalgia experienced by some patients with chronic fatigue syndrome (CFS) are due to abnormal cytokine production and leukocyte activity. Cytokines such as interleukin 1B (IL-1B) and tumor necrosis factor-a (TNFa) mediate fever and metabolic adaptations during infection. Exercise enhances production of these cytokines in healthy individuals, but an altered response may account for the exertionally-induced clinical signs and symptoms in CFS patients. In this study, cytokine production, along with associated leukocyte functions and metabolic responses will be measured before and after exercise in CFS patients and control subjects. A demonstration of abnormal cytokine production after exercise could help to explain the pathogenesis of an illness that at present is poorly understood. In addition, such information may lead to effective therapy; cytokine production can be influenced by dietary modifications, and cytokine activity can be altered by receptor antagonists and soluble receptors that are currently undergoing clinical trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033414-02
Application #
2068413
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1993-04-01
Project End
1996-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Daun, J M; Cannon, J G (2000) Macrophage migration inhibitory factor antagonizes hydrocortisone-induced increases in cytosolic IkappaBalpha. Am J Physiol Regul Integr Comp Physiol 279:R1043-9
Daun, J M; Ball, R W; Cannon, J G (2000) Glucocorticoid sensitivity of interleukin-1 agonist and antagonist secretion: the effects of age and gender. Am J Physiol Regul Integr Comp Physiol 278:R855-62
Daun, J M; Ball, R W; Burger, H R et al. (1999) Aspirin-induced increases in soluble IL-1 receptor type II concentrations in vitro and in vivo. J Leukoc Biol 65:863-6
Cannon, J G; Angel, J B; Ball, R W et al. (1999) Acute phase responses and cytokine secretion in chronic fatigue syndrome. J Clin Immunol 19:414-21
Corwin, E J; Cannon, J G (1999) Gonadotropin modulation of interleukin-1 secretion. J Gend Specif Med 2:30-4
Cannon, J G; St Pierre, B A (1998) Cytokines in exertion-induced skeletal muscle injury. Mol Cell Biochem 179:159-67
Cannon, J G; Abad, L W; Vannier, E et al. (1998) Menstrual- and gender-dependent variations in circulating IL-1 agonists, antagonists, and binding proteins. J Leukoc Biol 63:117-23
Cannon, J G; Angel, J B; Abad, L W et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol 17:253-61
Cannon, J G; St Pierre, B A (1997) Gender differences in host defense mechanisms. J Psychiatr Res 31:99-113
Lynch, E A; Dinarello, C A; Cannon, J G (1994) Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion. J Immunol 153:300-6

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