Mechanism of Immunosuppression by Leflunomide

Chong, Anita S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI034061-04
• Application #: 2069148
• Study Section: Surgery, Anesthesiology and Trauma Study Section (SAT)
• Project Start: 1993-03-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1998-02-28
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Rush University Medical Center
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60612

Publications

Siemasko, K; Chong, A S; Jack, H M et al. (1998) Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol 160:1581-8

Chong, A S; Shen, J; Xiao, F et al. (1996) Delayed xenograft rejection in the concordant hamster heart into Lewis rat model. Transplantation 62:90-6

Xiao, F; Chong, A; Shen, J et al. (1995) Pharmacologically induced regression of chronic transplant rejection. Transplantation 60:1065-72