Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034928-02
Application #
2070202
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Rigby, William F C; Roy, Kristen; Collins, Jane et al. (2005) Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function. J Immunol 174:7883-93
Brooks, Seth A; Connolly, John E; Rigby, William F C (2004) The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. J Immunol 172:7263-71
Hamilton, B JoNell; Genin, Anna; Cron, Randy Q et al. (2003) Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression. Mol Cell Biol 23:510-25
Brooks, Seth A; Connolly, John E; Diegel, Roger J et al. (2002) Analysis of the function, expression, and subcellular distribution of human tristetraprolin. Arthritis Rheum 46:1362-70
Pioli, P A; Rigby, W F (2001) The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression. J Biol Chem 276:40346-52
Brooks, S A; Rigby, W F (2000) Characterization of the mRNA ligands bound by the RNA binding protein hnRNP A2 utilizing a novel in vivo technique. Nucleic Acids Res 28:E49
Hamilton, B J; Nichols, R C; Tsukamoto, H et al. (1999) hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Biochem Biophys Res Commun 261:646-51
Rigby, W F; Waugh, M G; Hamilton, B J (1999) Characterization of RNA binding proteins associated with CD40 ligand (CD154) mRNA turnover in human T lymphocytes. J Immunol 163:4199-206
Hamilton, B J; Burns, C M; Nichols, R C et al. (1997) Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation. J Biol Chem 272:28732-41