Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034954-03
Application #
2070251
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1993-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ahmad, Iman M; Britigan, Bradley E; Abdalla, Maher Y (2011) Oxidation of thiols and modification of redox-sensitive signaling in human lung epithelial cells exposed to Pseudomonas pyocyanin. J Toxicol Environ Health A 74:43-51
Wen, Feng; Brown, Kyle E; Britigan, Bradley E et al. (2008) Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity. Cell Biol Toxicol 24:175-88
Reszka, Krzysztof J; Britigan, Bradley E (2007) Doxorubicin inhibits oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) by a lactoperoxidase/H(2)O(2) system by reacting with ABTS-derived radical. Arch Biochem Biophys 466:164-71
Wagner, Brett A; Teesch, Lynn M; Buettner, Garry R et al. (2007) Inactivation of anthracyclines by serum heme proteins. Chem Res Toxicol 20:920-6
Reszka, Krzysztof J; Denning, Gerene M; Britigan, Bradley E (2006) Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa. Photochem Photobiol 82:466-73
Lau, Gee W; Hassett, Daniel J; Britigan, Bradley E (2005) Modulation of lung epithelial functions by Pseudomonas aeruginosa. Trends Microbiol 13:389-97
Abdalla, Maher Y; Ahmad, Iman M; Spitz, Douglas R et al. (2005) Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol 76:489-97
Lau, Gee W; Britigan, Bradley E; Hassett, Daniel J (2005) Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils. Infect Immun 73:2550-3
Uc, Aliye; Husted, Russell F; Giriyappa, Radhamma L et al. (2005) Hemin induces active chloride secretion in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 289:G202-8
Reszka, Krzysztof J; Wagner, Brett A; Teesch, Lynn M et al. (2005) Inactivation of anthracyclines by cellular peroxidase. Cancer Res 65:6346-53

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