Regulation of Complement Damage by Immunoglobulin

Frank, Michael M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI035033-03
• Application #: 2070384
• Study Section: Immunological Sciences Study Section (IMS)
• Project Start: 1993-12-01
• Project End: 1998-11-30
• Budget Start: 1995-12-01
• Budget End: 1996-11-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Duke University
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 071723621
• City: Durham
• State: NC
• Country: United States
• Zip Code: 27705

Publications

Wagner, E; Platt, J L; Howell, D N et al. (1999) IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model. J Immunol 163:3549-58

Wagner, E; Platt, J L; Frank, M M (1998) High dose intravenous immunoglobulin does not affect complement-bacteria interactions. J Immunol 160:1936-43

Miletic, V D; Hester, C G; Frank, M M (1996) Regulation of complement activity by immunoglobulin. I. Effect of immunoglobulin isotype on C4 uptake on antibody-sensitized sheep erythrocytes and solid phase immune complexes. J Immunol 156:749-57

Miletic, V D; Frank, M M (1995) Complement-immunoglobulin interactions. Curr Opin Immunol 7:41-7