Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI035098-03
Application #
2070492
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Hsia, Hung-Ching; Hutti, Jessica E; Baldwin, Albert S (2017) Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem 292:5405-5417
Hsia, Hung-Ching; Stopford, Charles M; Zhang, Zhigang et al. (2017) Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection. J Leukoc Biol 101:1053-1064
Bradford, Jennifer W; Baldwin, Albert S (2014) IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironment. Adv Cancer Res 121:125-145
Dan, Han C; Ebbs, Aaron; Pasparakis, Manolis et al. (2014) Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by I?B kinase ? (IKK?). J Biol Chem 289:25227-40
Kendellen, M F; Bradford, J W; Lawrence, C L et al. (2014) Canonical and non-canonical NF-?B signaling promotes breast cancer tumor-initiating cells. Oncogene 33:1297-305
Stein, Sarah J; Baldwin, Albert S (2013) Deletion of the NF-?B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function. Blood 121:5015-24
Hutti, Jessica E; Porter, Melissa A; Cheely, Adam W et al. (2012) Development of a high-throughput assay for identifying inhibitors of TBK1 and IKK?. PLoS One 7:e41494
Awwad, Yousef; Geng, Tao; Baldwin, Albert S et al. (2012) Observing single cell NF-?B dynamics under stimulant concentration gradient. Anal Chem 84:1224-8
Hutti, Jessica E; Pfefferle, Adam D; Russell, Sean C et al. (2012) Oncogenic PI3K mutations lead to NF-ýýB-dependent cytokine expression following growth factor deprivation. Cancer Res 72:3260-9
Comb, William C; Hutti, Jessica E; Cogswell, Patricia et al. (2012) p85ýý SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol Cell 45:719-30

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