Interleukin-12 as Immunotherapy in Leishmaniasis

Heinzel, Frederick P.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI035979-03
• Application #: 2071989
• Study Section: Special Emphasis Panel (SRC (40))
• Project Start: 1994-09-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Case Western Reserve University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Greene, Jennifer A; DeVecchio, Jennifer L; Gould, Meetha P et al. (2006) In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN. J Immunol 176:5995-6003

Das, Lopamudra; DeVecchio, Jennifer; Heinzel, Frederick P (2005) Fms-like tyrosine kinase 3-based immunoprophylaxis against infection is improved by adjuvant treatment with anti-interleukin-10 antibody. J Infect Dis 192:693-702

Yadavalli, Gopala K; Chien, Jason W; Wener, Kenneth M et al. (2005) Interleukin 12 and interferon-gamma synthetic deficiency is associated with dendritic cell cytopenia after cardiac surgery. Shock 24:26-33

Gould, Meetha P; Greene, Jennifer A; Bhoj, Vijay et al. (2004) Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis. J Immunol 172:1754-62

Murray, Henry W; Brooks, Elaine B; DeVecchio, Jennifer L et al. (2003) Immunoenhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis. Antimicrob Agents Chemother 47:2513-7

Garhart, Christine A; Nedrud, John G; Heinzel, Frederick P et al. (2003) Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun 71:3628-33

Murray, Henry W; Lu, Cristina M; Brooks, Elaine B et al. (2003) Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis. Infect Immun 71:6453-62

Garhart, Christine A; Heinzel, Frederick P; Czinn, Steven J et al. (2003) Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun 71:910-21

Murray, Henry W; Moreira, Andre L; Lu, Cristina M et al. (2003) Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis. J Infect Dis 188:458-64

Khatri, Saloni; Lass, Jonathan H; Heinzel, Fred P et al. (2002) Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4. Invest Ophthalmol Vis Sci 43:2278-84