Enhanced Safety & Efficacy of AIDS Vaccines by Ifn Delta

Yilma, Tilahun D.

Abstract

The general scope of this project is to demonstrate that an SIV, with the nef gene replaced by the g-interferon gene, could be a safer and more immunogenic live attenuated vaccine in macaques than the SIVd-nef.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 5R01AI036197-03
• Application #: 2886925
• Study Section: AIDS and Related Research Study Section 3 (ARRC)
• Program Officer: Bradac, James A
• Project Start: 1997-04-15
• Project End: 2000-03-31
• Budget Start: 1999-04-01
• Budget End: 2000-03-31
• Support Year: 3
• Fiscal Year: 1999

Institution

• Name: University of California Davis
• Department: Veterinary Sciences
• Type: Schools of Veterinary Medicine
• DUNS #: 094878337
• City: Davis
• State: CA
• Country: United States
• Zip Code: 95618

Publications

Yilma, Tilahun; Verardi, Paulo; Jones, Leslie (2010) Development of safe and efficacious viral vaccines for animals. Crit Rev Immunol 30:223-37

Yilma, T; Aziz, F; Ahmad, S et al. (2003) Inexpensive vaccines and rapid diagnostic kits tailor-made for the global eradication of rinderpest, and technology transfer to Africa and Asia. Dev Biol (Basel) 114:99-111

Verardi, Paulo H; Aziz, Fatema H; Ahmad, Shabbir et al. (2002) Long-term sterilizing immunity to rinderpest in cattle vaccinated with a recombinant vaccinia virus expressing high levels of the fusion and hemagglutinin glycoproteins. J Virol 76:484-91

Verardi, P H; Jones, L A; Aziz, F H et al. (2001) Vaccinia virus vectors with an inactivated gamma interferon receptor homolog gene (B8R) are attenuated In vivo without a concomitant reduction in immunogenicity. J Virol 75:11-8

Jones, L; Ahmad, S; Chan, K et al. (2000) Enhanced safety and efficacy of live attenuated SIV vaccines by prevaccination with recombinant vaccines. J Med Primatol 29:231-9

Gauduin, M C; Glickman, R L; Ahmad, S et al. (1999) Characterization of SIV-specific CD4+ T-helper proliferative responses in macaques immunized with live-attenuated SIV. J Med Primatol 28:233-41