The application describes previous studies in which systemic priming of rhesus macaques with formalin-inactivated whole SIV in microspheres, followed by oral or intratracheal boosting with the microencapsulated vaccine, resulted in significant protection against intravaginal challenge with live pathogenic SIV. The application also describes various proposed approaches to improve upon mucosal immunization including: (1) utilizing recombinant vaccinia virus expression systems for the production of non-infectious virus-like particles (VLP's) to be used as antigens in microencapsulated vaccines, (2) developing recombinant baculovirus expression systems for expression of SIV and HIV virus-like particles, and (3) developing approaches for mucosal immunization with non-replicating plasmids encoding HIV and SIV antigens. (Adapted from the Application).

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI036598-02
Application #
2072958
Study Section
Special Emphasis Panel (SRC)
Project Start
1994-02-01
Project End
1998-01-31
Budget Start
1995-02-01
Budget End
1996-01-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Aaron Diamond AIDS Research Center
Department
Type
DUNS #
786658872
City
New York
State
NY
Country
United States
Zip Code
10016