Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI037320-02
Application #
2074025
Study Section
Special Emphasis Panel (ZRG5-TMP (02))
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Ge, Xue; Penney, Lisa C; van de Rijn, Ivo et al. (2004) Active site residues and mechanism of UDP-glucose dehydrogenase. Eur J Biochem 271:14-22
Campbell, R E; Mosimann, S C; van De Rijn, I et al. (2000) The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation. Biochemistry 39:7012-23
Bernish, B; van de Rijn, I (1999) Characterization of a two-component system in Streptococcus pyogenes which is involved in regulation of hyaluronic acid production. J Biol Chem 274:4786-93
Manganelli, R; van de Rijn, I (1999) Characterization of emb, a gene encoding the major adhesin of Streptococcus defectivus. Infect Immun 67:50-6
Sunthankar, P; Pastuszak, I; Rooke, A et al. (1998) Synthesis of 5-azido-UDP-N-acetylhexosamine photoaffinity analogs and radiolabeled UDP-N-acetylhexosamines. Anal Biochem 258:195-201
van de Rijn, I; Bernish, B; Crater, D L (1997) Analysis of hyaluronic acid capsule expression in group A streptococci. Adv Exp Med Biol 418:965-9
Campbell, R E; Sala, R F; van de Rijn, I et al. (1997) Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetol. J Biol Chem 272:3416-22
Crater, D L; Dougherty, B A; van de Rijn, I (1995) Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity. J Biol Chem 270:28676-80
Crater, D L; van de Rijn, I (1995) Hyaluronic acid synthesis operon (has) expression in group A streptococci. J Biol Chem 270:18452-8