Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038177-02
Application #
2075116
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1995-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Miller, Michelle M; Petty, Christopher S; Tompkins, Mary B et al. (2014) CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGF? / GARP-mediated mechanism. Virol J 11:7
Mexas, Angela M; Fogle, Jonathan E; Tompkins, Wayne A et al. (2008) CD4+CD25+ regulatory T cells are infected and activated during acute FIV infection. Vet Immunol Immunopathol 126:263-72
Tompkins, Mary B; Tompkins, Wayne A (2008) Lentivirus-induced immune dysregulation. Vet Immunol Immunopathol 123:45-55
Petty, Christopher S; Tompkins, Mary B; Tompkins, Wayne A (2008) Transforming growth factor-beta/transforming growth factor-betaRII signaling may regulate CD4+CD25+ T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection. J Acquir Immune Defic Syndr 47:148-60
Smithberg, S Rochelle; Fogle, Jonathan E; Mexas, Angela M et al. (2008) In vivo depletion of CD4+CD25+ regulatory T cells in cats. J Immunol Methods 329:81-91
Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B et al. (2005) Different thresholds of T cell activation regulate FIV infection of CD4+CD25+ and CD4+CD25- cells. Virology 335:212-21
Vahlenkamp, Thomas W; Tompkins, Mary B; Tompkins, Wayne A F (2005) The role of CD4+CD25+ regulatory T cells in viral infections. Vet Immunol Immunopathol 108:219-25
Joshi, Anjali; Garg, Himanshu; Tompkins, Mary B et al. (2005) Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. J Virol 79:4965-76
Joshi, Anjali; Vahlenkamp, Thomas W; Garg, Himanshu et al. (2004) Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation. Virology 321:307-22
Levy, Julie K; Liang, Yinghua; Ritchey, Jerry W et al. (2004) Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells. Vet Immunol Immunopathol 98:101-11

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