Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI038200-02
Application #
2075162
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1995-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Lin, Stephen S; Manchester, Jill K; Gordon, Jeffrey I (2003) Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing. J Biol Chem 278:13390-7
Lin, S S; Manchester, J K; Gordon, J I (2001) Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae. J Biol Chem 276:36000-7
Farazi, T A; Waksman, G; Gordon, J I (2001) The biology and enzymology of protein N-myristoylation. J Biol Chem 276:39501-4
Farazi, T A; Manchester, J K; Waksman, G et al. (2001) Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. Biochemistry 40:9177-86
Farazi, T A; Waksman, G; Gordon, J I (2001) Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry 40:6335-43
Futterer , K; Murray , C L; Bhatnagar , R S et al. (2001) Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA. Acta Crystallogr D Biol Crystallogr 57:393-400
Farazi, T A; Manchester, J K; Gordon, J I (2000) Transient-state kinetic analysis of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase reveals that a step after chemical transformation is rate limiting. Biochemistry 39:15807-16
Hassan, B A; Bellen, H J (2000) Doing the MATH: is the mouse a good model for fly development? Genes Dev 14:1852-65
Ashrafi, K; Lin, S S; Manchester, J K et al. (2000) Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14:1872-85
Ashrafi, K; Sinclair, D; Gordon, J I et al. (1999) Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96:9100-5

Showing the most recent 10 out of 20 publications