Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI038960-01
Application #
2076073
Study Section
Special Emphasis Panel (ZRG3-MEP (01))
Project Start
1996-02-15
Project End
2001-01-31
Budget Start
1996-02-15
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Ish-Shalom, Eliran; Gargir, Ari; Andre, Sabine et al. (2006) alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells. Glycobiology 16:173-83
Mishan-Eisenberg, Galit; Borovsky, Zipora; Weber, Matthew C et al. (2004) Differential regulation of Th1/Th2 cytokine responses by placental protein 14. J Immunol 173:5524-30
Rachmilewitz, Jacob; Borovsky, Zipora; Riely, Gregory J et al. (2003) Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45. J Biol Chem 278:14059-65
Tykocinski, Mark L; Chen, Aoshuang; Huang, Jui-Han et al. (2003) New designs for cancer vaccine and artificial veto cells: an emerging palette of protein paints. Immunol Res 27:565-74
Rachmilewitz, Jacob; Borovsky, Zipora; Mishan-Eisenberg, Galit et al. (2002) Focal localization of placental protein 14 toward sites of TCR engagement. J Immunol 168:2745-50
Moody, D Branch; Briken, Volker; Cheng, Tan-Yun et al. (2002) Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat Immunol 3:435-42
Rachmilewitz, J; Riely, G J; Huang, J H et al. (2001) A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds. Blood 98:3727-32
Riely, G J; Rachmilewitz, J; Koo, P H et al. (2000) alpha2-macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14. Biochem J 351 Pt 2:503-8
Rachmilewitz, J; Riely, G J; Tykocinski, M L (1999) Placental protein 14 functions as a direct T-cell inhibitor. Cell Immunol 191:26-33
Rachmilewitz, J; Tykocinski, M L (1998) Differential effects of chondroitin sulfates A and B on monocyte and B-cell activation: evidence for B-cell activation via a CD44-dependent pathway. Blood 92:223-9

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