Abstract

The specific aims of this proposal are to conduct studies in the context of an ongoing clinical trial in Uganda of pneumococcal vaccine efficacy in Ugandan patients with HIV infection, to determine if progression of HIV infection is promoted by pneumococcal infection or vaccination, and to determine reasons for increased risk of pneumococcal disease in HIV infected patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI039445-03
Application #
2672701
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
2000-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Boulware, David R; Daley, Charles L; Merrifield, Cynthia et al. (2007) Rapid diagnosis of pneumococcal pneumonia among HIV-infected adults with urine antigen detection. J Infect 55:300-9
Gordon, Stephen B; Janoff, Edward N; Sloper, Dan et al. (2005) HIV-1 infection is associated with altered innate pulmonary immunity. J Infect Dis 192:1412-6
Scamurra, Ronald W; Nelson, Douglas B; Lin, Xue Mei et al. (2002) Mucosal plasma cell repertoire during HIV-1 infection. J Immunol 169:4008-16
Finn, Adam; Zhang, Qibo; Seymour, Lynn et al. (2002) Induction of functional secretory IgA responses in breast milk, by pneumococcal capsular polysaccharides. J Infect Dis 186:1422-9
Janoff, E N; Smith, P D (2001) Emerging concepts in gastrointestinal aspects of HIV-1 pathogenesis and management. Gastroenterology 120:607-21
Carson, P J; Nichol, K L; O'Brien, J et al. (2000) Immune function and vaccine responses in healthy advanced elderly patients. Arch Intern Med 160:2017-24
Scamurra, R W; Miller, D J; Dahl, L et al. (2000) Impact of HIV-1 infection on VH3 gene repertoire of naive human B cells. J Immunol 164:5482-91
French, N; Nakiyingi, J; Carpenter, L M et al. (2000) 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial. Lancet 355:2106-11
Wahl, S M; Smith, P D; Janoff, E N (1999) Human immunodeficiency virus type 1 infection, mucosal immunity, and pathogenesis: comments and conference summary. J Infect Dis 179 Suppl 3:S397-400
Janoff, E N; Scamurra, R W; Sanneman, T C et al. (1999) Human immunodeficiency virus type 1 and mucosal humoral defense. J Infect Dis 179 Suppl 3:S475-9

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