Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI039616-01A1
Application #
2004662
Study Section
Experimental Virology Study Section (EVR)
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Pavlova, Iglika V; Virgin 4th, Herbert W; Speck, Samuel H (2003) Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication. J Virol 77:5731-9
Moorman, Nathaniel J; Virgin 4th, Herbert W; Speck, Samuel H (2003) Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency. Virology 307:179-90
Clambey, Eric T; Virgin 4th, Herbert W; Speck, Samuel H (2002) Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency. J Virol 76:6532-44
Tibbetts, Scott A; van Dyk, Linda F; Speck, Samuel H et al. (2002) Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. J Virol 76:7125-32
Jacoby, Meagan A; Virgin 4th, Herbert W; Speck, Samuel H (2002) Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation. J Virol 76:1790-801
Gangappa, Shivaprakash; van Dyk, Linda F; Jewett, Travis J et al. (2002) Identification of the in vivo role of a viral bcl-2. J Exp Med 195:931-40
Talloczy, Zsolt; Jiang, Wenxia; Virgin 4th, Herbert W et al. (2002) Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A 99:190-5
Gil, M P; Bohn, E; O'Guin, A K et al. (2001) Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 98:6680-5
Presti, R M; Popkin, D L; Connick, M et al. (2001) Novel cell type-specific antiviral mechanism of interferon gamma action in macrophages. J Exp Med 193:483-96
van Berkel, V; Barrett, J; Tiffany, H L et al. (2000) Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action. J Virol 74:6741-7

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