The PI proposes experiments to understand the noncytolytic inhibition of HIV mediated by CD8+ T cells. The goals are to: a) identify the factors, b) define the mechanisms, c) identify viral determinants which allow susceptibility. The PI will study whether inhibition occurs at integration or inhibition of expression. He also will characterize the factors from the Herpes-virus saimiri line that he has developed and examine the chemokines recently reported to be involved. The overall goal is to understand the basis for CD8 HIV inhibitory activity and may facilitate therapies for HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040017-05
Application #
6169954
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Bridges, Sandra H
Project Start
1996-07-01
Project End
2002-05-31
Budget Start
2000-06-01
Budget End
2002-05-31
Support Year
5
Fiscal Year
2000
Total Cost
$280,436
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705