Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI040114-01
Application #
2077039
Study Section
Special Emphasis Panel (ZRG2-ALY (01))
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Castro, Iris; Dee, Michael J; Malek, Thomas R (2012) Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells. J Immunol 189:4321-30
Castro, Iris; Yu, Aixin; Dee, Michael J et al. (2011) The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. J Immunol 187:5170-82
Yu, Aixin; Zhu, Linjian; Altman, Norman H et al. (2009) A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 30:204-17
Rolle, Cleo E; Carrio, Roberto; Malek, Thomas R (2008) Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy. Cancer Res 68:2984-92
Carrio, Roberto; Rolle, Cleo E; Malek, Thomas R (2007) Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells. Eur J Immunol 37:3078-88
Gong, Dapeng; Malek, Thomas R (2007) Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol 178:242-52
Jin, Haoli; Malek, Thomas R (2006) Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21. J Leukoc Biol 80:1416-23
Jin, Haoli; Gong, Dapeng; Adeegbe, Dennis et al. (2006) Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo. Int Immunol 18:565-72
Bayer, Allison L; Yu, Aixin; Adeegbe, Dennis et al. (2005) Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med 201:769-77
Jin, Haoli; Carrio, Roberto; Yu, Aixin et al. (2004) Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 173:657-65

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