Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI041768-20
Application #
6725511
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Johnson, David R
Project Start
1980-09-01
Project End
2006-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
20
Fiscal Year
2004
Total Cost
$325,000
Indirect Cost

  Institution

Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Zheng, Song Guo; Wang, Juhua; Wang, Pu et al. (2007) IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 178:2018-27
Zheng, Song Guo; Wang, Ju Hua; Stohl, William et al. (2006) TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol 176:3321-9
Horwitz, David A; Zheng, Song Guo; Gray, J Dixon et al. (2004) Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease. Semin Immunol 16:135-43
Zheng, Song Guo; Wang, Ju Hua; Koss, Michael N et al. (2004) CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 172:1531-9
Zheng, Song Guo; Wang, Ju Hua; Gray, J Dixon et al. (2004) Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 172:5213-21
Horwitz, David A; Zheng, Song Guo; Gray, J Dixon (2003) The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 74:471-8
Zheng, Song Guo; Gray, J Dixon; Ohtsuka, Kazuo et al. (2002) Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol 169:4183-9
Gray, J D; Liu, T; Huynh, N et al. (2001) Transforming growth factor beta enhances the expression of CD154 (CD40L) and production of tumor necrosis factor alpha by human T lymphocytes. Immunol Lett 78:83-8
Yamagiwa, S; Gray, J D; Hashimoto, S et al. (2001) A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 166:7282-9
Ohtsuka, K; Gray, J D; Quismorio Jr, F P et al. (1999) Cytokine-mediated down-regulation of B cell activity in SLE: effects of interleukin-2 and transforming growth factor-beta. Lupus 8:95-102

Showing the most recent 10 out of 14 publications