Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI041937-01S1
Application #
2712010
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1997-09-01
Project End
2000-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Genetics
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Kojima, Kaihei; Bahn, Yong-Sun; Heitman, Joseph (2006) Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology 152:591-604
Onyewu, Chiatogu; Wormley Jr, Floyd L; Perfect, John R et al. (2004) The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun 72:7330-3
Waugh, Michael S; Vallim, Marcelo A; Heitman, Joseph et al. (2003) Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. Fungal Genet Biol 38:110-21
Alspaugh, J Andrew; Pukkila-Worley, Read; Harashima, Toshiaki et al. (2002) Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell 1:75-84
Chung, N; Mao, C; Heitman, J et al. (2001) Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem 276:35614-21
Cruz, M C; Goldstein, A L; Blankenship, J et al. (2001) Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob Agents Chemother 45:3162-70
Rohde, J; Heitman, J; Cardenas, M E (2001) The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276:9583-6
Cruz, M C; Fox, D S; Heitman, J (2001) Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. EMBO J 20:1020-32
Alspaugh, J A; Davidson, R C; Heitman, J (2000) Morphogenesis of Cryptococcus neoformans. Contrib Microbiol 5:217-38
Chung, N; Jenkins, G; Hannun, Y A et al. (2000) Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem 275:17229-32

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